Integrative study of HPV infection associated with the Nuclear Pore Complex
Integrative study of HPV infection associated with the Nuclear Pore Complex
HPV (Human Papilloma Virus) is a common type of virus. It can be found in 30% of women and 50% of men in the world. Ultimately, it causes cervical cancer in 20% of women.
The virus is composed of 2 main parts. One is the genetic material (DNA or RNA) and the other is a protein shell, called capsid.
The virus have to put its DNA into the nucleus of the host cell to replicate itself.
During the genetic material injection process, the virus have to interact with Nuclear Pore Complex (NPC), a protein complex located in the nucleus membrane and deals with transporting.
Our purpose is to study and clarify a specific mechanism of this process.
Using integrative approach, we can explore the NPC-virus interaction in various scale with diverse techniques.
With diverse type of techniques, we can first directly see what is happening inside.
Furthermore, we will integrate the data from each techniques and computational analysis to get the best model to understand the virus-NPC complex, ultimately, explaining the molecular mechanism of injection of the virus's genetic material to the host cell's nucleus.
